Prevalence of Poor Sleep Quality and its Association with Lifestyle Habits, Competition-Based Activities, and Psychological Distress in Japanese Student-Athletes During the COVID-19 Pandemic.

Objectives The present study clarified the prevalence of poor sleep quality and its relation to lifestyle habits, competitive-based activities, and psychological distress among Japanese student-athletes in the initial pandemic period (2020) and 1 year later (2021). Methods In the present study, student-athletes were defined as individuals belonging to university athletic clubs. The data of two cross-sectional surveys (2020: n = 961 and 2021: n = 711) were collected from student-athletes in 6 universities in Japan. First, the prevalence of poor sleep quality (Pittsburgh sleep quality index score > 5) was investigated. Relationships between poor sleep quality and lifestyle habits, competition-based activities, and psychological distress were then explored using multivariate logistic regression analysis adjusted for age, sex, and body mass index. Results The prevalence of poor sleep quality was 33.6% in 2020 and 36.6% in 2021. Poor sleep quality in 2020 was related to late bedtime, taking supplements before bed, part-time job (no late night), stressors of expectations and pressure from others, and psychological distress, whereas that in 2021 was related to early wake-up time, skipping breakfast, taking caffeinated drinks before bed, use of smartphone/cellphone after lights out, stressors of motivation loss, and psychological distress. Conclusions In both 2020 and 2021, one-third of student-athletes had poor sleep quality and psychological distress was its common risk factor. Lifestyle habits and competition stressors associated with poor sleep quality were pandemic-specific in 2020, but similar to the prepandemic period in 2021.

Health Problems Related to Presenteeism Among Japanese Employees.

OBJECTIVE: This study identified primary health problems related to presenteeism stratified by sex. METHODS: A cross-sectional study was conducted to analyze the relationship between 26 health problems and presenteeism using data from health-related data and World Health Organization Health and Work Performance Questionnaire among 12,526 employees in Japan. RESULTS: Sex-stratified multiple regression analyses showed that presenteeism was associated with nine health problems in both sexes, depressive symptoms, followed by lack of appetite, insufficient sleep, heart palpitations, or shortness of breath demonstrated the strongest relationship. Men had five additional health problems associated with presenteeism; furthermore, the relationships of those were stronger than women. CONCLUSIONS: The primary health problems related to presenteeism were depressive symptoms and indefinite complaints in both sexes. Men had more and stronger relationship between health problems and presenteeism than women.

Development of adolescent childhood cancer survivors' psychosocial issues scale.

BACKGROUND: Follow-up care for adolescent childhood cancer survivors (ACCS) after they return to school requires an understanding of their psychosocial issues. Therefore, this study developed the adolescent childhood cancer survivors' psychosocial issues scale (ACCSPIS) and evaluated its reliability and validity. METHODS: In the development phase, pediatric oncology clinical professionals created the 24 item questionnaire of ACCS's psychosocial issues. In the feasibility phase, a survey was administered to 165 ACCS aged 12-18 years after discharge from hospital in Japan, and 57 completed questionnaires were analyzed. The survey items were psychosocial issues, attributes, K6 scale, and impact of event scale-revised (IES-R) scale. Factor analysis was conducted for psychosocial issues. Regarding reliability, Cronbach's α coefficients and item-total correlation coefficients were calculated. Regarding validity, Spearman's rank correlation coefficients between ACCSPIS and K6 and IES-R were calculated, and confirmatory factor analysis was conducted. RESULTS: Four factors comprising 15 items were extracted: "appearance changes due to treatment effects," "anxiety about marriage and the future," "change in appearance due to treatment", and "psychological distress due to interpersonal relationships and information about the disease." The model fit was good, with a total ACCSPIS α coefficient of 0.901 and α coefficients for the subscales ranging from 0.651 to 0.914. The K6 and IES-R were significantly associated with the total ACCSPIS, and item-total correlations were satisfactory. CONCLUSIONS: The reliability and validity of ACCSPIS were generally confirmed. This scale could be useful to measure psychosocial issues in ACCS aged 12-18 years after their return to school.

A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment.

Ryanodine receptor 2 (RyR2) is a Ca2+ release channel mainly located on the sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the concentration of Ca2+ in the cytosol. RyR2 overactivation causes potentially lethal cardiac arrhythmias, but no specific inhibitor is yet available. Herein we developed the first highly potent and selective RyR2 inhibitor, TMDJ-035, containing 3,5-difluoro substituents on the A ring and a 4-fluoro substituent on the B ring, based on a comprehensive structure-activity relationship (SAR) study of tetrazole compound 1. The SAR study also showed that the amide conformation is critical for inhibitory potency. Single-crystal X-ray diffraction analysis and variable-temperature 1H NMR revealed that TMDJ-035 strongly favors cis-amide configuration, while the inactive analogue TMDJ-011 with a secondary amide takes trans-amide configuration. Examination of the selectivity among RyRs indicated that TMDJ-035 displayed high selectivity for RyR2. TMDJ-035 suppressed abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. It appears to be a promising candidate drug for treating cardiac arrhythmias due to RyR2 overactivation, as well as a tool for studying the mechanism and dynamics of RyR2 channel gating.

Solvent-Dependent Conformational Switching of N-Methyl-N,N'-diarylsquaramide.

N,N'-Diarylsquaramide and N,N'-dialkylsquaramide are conformationally stable linkers with extended (trans, trans) and folded (cis, cis) structures, respectively, independently of external conditions. Here, we show that N-monomethylated N,N'-diarylsquaramides generally take a (trans, cis) structure in the crystal but show a solvent-dependent conformational equilibrium in solution. In particular, the stable conformer of N-methyl-N,N'-bis(1-naphthyl)squaramide (1f) changes depending upon the solvent. Thus, aromatic N-monomethylated squaramides could find application as components of environment-responsive molecular switches.

Mental Health and Psychosocial Status in Mothers of Children with Attention Deficit Hyperactivity Disorder (ADHD): Differences by Maternal ADHD Tendencies : Mental Health and Psychosocial Status in Mothers of ADHD Children.

This study clarified differences in mental health, psychosocial status, and mental health-related factors among mothers of ADHD children between those with and without maternal ADHD tendencies from data of 149 mothers of children with ADHD through an online survey. Mothers with ADHD tendencies had poorer mental health, lower education, more ADHD children, and more parenting stressor of "inadequate understanding of the child's disorder from others" than mothers without ADHD tendencies. Their mental health was poorer especially in younger and in those who had more parenting stressors of "difficulties in understanding the child and coping with the child's needs" and "inadequate understanding of the child's disorder from others." Mental health in mothers without ADHD tendencies was related to a variety of parenting stressors and severe ADHD symptoms in the child. Therefore, assessing maternal ADHD tendencies may be necessary to consider effective individualized support measures for mothers of ADHD children.

Prevalence and risk factors of poor subjective sleep quality in elite judo athletes.

This study aimed to determine the prevalence and risk factors of poor subjective sleep quality in elite judo athletes. A subjective cross-sectional questionnaire survey was conducted with 106 elite judo athletes who participated in the training camp of the Japanese national team. Eighty-six respondents (men: 52.3%; average age: 22.9 ± 3.1 years) with complete responses were included in the analysis (valid response rate: 81.1%). Subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). The prevalence of poor sleep quality (PSQI score ≥ 5.5), the mean PSQI score, and subscale scores were investigated. Relationships between poor sleep quality and attributes, lifestyle habits, competition-based activities, and psychological distress were explored using Fisher's exact tests and multivariate logistic regression analysis. Thirty-five respondents (40.7%) reported poor sleep quality. The percentage and subscale scores of the respondents for sleep latency, sleep duration, and daytime dysfunction were higher than those of the population of Japanese national-level athletes. The mean PSQI score of the respondents was similar to that of some elite athlete populations but higher than those of others. Multivariate logistic regression analysis revealed that psychological distress was associated with poor sleep quality. In conclusion, the prevalence of poor subjective sleep quality in elite judo athletes was suggested to be similar or higher among elite athlete population. Sleep latency, sleep duration, and daytime dysfunction status were worse in elite judo athletes than in Japanese national-level athletes. Psychological distress was a risk factor for poor subjective sleep quality in elite judo athletes. Supplementary Information: The online version contains supplementary material available at 10.1007/s41105-023-00444-6.

Risk factors for multiple metabolic syndrome components in obese and non-obese Japanese individuals.

Many studies have reported that even non-obese individuals have multiple metabolic syndrome (MetS) components, such as hypertension, hyperglycemia, and lipid abnormalities have a higher cardiovascular disease mortality rate and incidence. However, the risk factors for multiple MetS components in non-obese individuals have not been sufficiently clarified. This study compared risk factors, including overall lifestyle habits, for multiple MetS components possession between obese and non-obese individuals. A cross-sectional study was conducted using data from specific health checkups of 47,172 individuals (age, 40-64 years) who belonged to the health insurance societies of five manufacturing companies in Japan in 2015. Multiple logistic regression analysis was conducted in the non-obese and obese groups with multiple MetS components as the objective variable, and attributes, body weight change, and 11 lifestyle habits (smoking, exercise, diet, drinking, and sleep) as explanatory variables. For both groups, men, older age, current smoking, weight gain of ≥10 kg since age of 20, slow walking speed, fast eating speed, and greater amounts of alcohol consumption were risk factors for having multiple MetS components. The odds ratio of each risk factor, with the exception of walking speed and eating speed, tended to be higher in non-obese individuals than in obese individuals. The only risk factor specific to obese individuals was lack of regular exercise. These results suggest that almost all risk factors for possession of multiple MetS components were common to both obese and non-obese individuals, and the risk level of each risk factor tended to be higher in non-obese individuals.

[The psychological process and its longitudinal of family caregivers involved in associations for families of dementia patients].

AIM: This study aimed to explore the psychological and dynamic process of modification and evaluate its time-series peculiarity in family caregivers involved in associations for the families of dementia patients. METHODS: The current study included 39 family caregivers involved in two associations for the families of dementia patients. Five-year free group conversations in the family caregivers were recorded and converted into a verbatim record. The KJ method was then used to encode and group the verbatim record. After analyzing grouped terms and structuring the psychological and dynamic process of modification, time periods of the psychological status were determined based on the psychological process and the time-oriented perspective. The verbatim record extracted by the KJ method was analyzed by text-mining and a cluster analysis in order to assess validity of the psychological process and its time division. In addition, the appearance ratio of the texts extracted in each time period were analyzed to determine the longitudinal peculiarity in the psychological and dynamic process. RESULTS: The psychological process of family caregivers was classified broadly into four components: (1) recognizing and identifying problems, (2) seeking help and dealing with problems, (3) remedying and evaluating problems, and (4) feeling effective and empowering oneself to overcome problems. The validity of the psychological process and its time division was supported by text-mining and a cluster analysis. The appearance ratio of the texts extracted in each time period was quasi-periodic and recursive rather than transient. CONCLUSIONS: The psychological and dynamic process elucidated in the current study consists of four major components participants experience when involved in associations for the families of dementia patients. Although this process may not have originated in associations for the families of dementia patients, a quasi-periodic and recursive tendency in the appearance ratio of extracted texts is a notable feature. In dementia care, it is vital to foresee emerging challenges on a constant basis and attempt precedent, forecasting-type care. Being involved in associations for the families of dementia patients facilitates the administration of forecasting-type care.

Prevalence and risk factors of sleep disorders in visually impaired athletes.

OBJECTIVE: The present study clarified the prevalence and risk factors of sleep disorders in visually impaired athletes. METHODS: A cross-sectional questionnaire survey was conducted with 99 visually impaired athletes engaged in the following Paralympic sport events: track and field (marathon), goalball, swimming, blind soccer, and judo. Eighty-one respondents (male: 72.8%; average age: 32.5 ± 12.0 years) who completed the survey were chosen for analyses. Survey items were attributes [age, gender, body mass index, and condition of visual impairment (athletic classification and causing time of disability)], lifestyle habits (bedtime, wake-up time, drinking alcohol, meals, and use of electronics after lights out), competition activities (sports time per week, morning and evening practices, and competition stressors), psychological distress, and sleep disorders [recorded using the Pittsburgh Sleep Quality Index (PSQI)]. First, the prevalence of the respondents having sleep disorders (scored 5.5 points or more in the PSQI) was investigated. Then, the relations between attributes, lifestyle habits, competition activities, psychological distress, and sleep disorders were explored using logistic regression analysis. RESULTS: Twenty-six respondents (32.1%) had sleep disorders. Results of multivariate logistic regression analysis showed that "interpersonal relationship stressors" and "wake-up time" were independently related to sleep disorders. CONCLUSIONS: Approximately one-third of visually impaired athletes were shown to have sleep disorders. High interpersonal relationship stressors and late wake-up time may be risk factors of their sleep disorders.

Mental Health Status and Related Factors Among Visually Impaired Athletes.

BACKGROUND: A growing body of pieces of evidence suggests that sport activity is of potential importance both for physical and mental health. To date, there is a lack of information and evidence regarding the mental health of visually impaired people playing some extent of sports and recognized as athletes with renowned career track. The present study aims to clarify the mental health status and its related factors in visually impaired athletes. METHODS: The current study was a questionnaire-based cross-sectional investigation. Visually impaired athletes (n = 81; men: 72.8%; average age: 32.8 ± 12.0 years) engaged in Paralympic sports events namely track and field (marathon), goalball, swimming, blind soccer, and judo were the study subjects from leading institutions in Japan. A diverse range of issues were included in a questionnaire survey like attributes, condition of visual impairment, competition activities, competition stressors, social support, and mental health status (recorded through the K6 scale). Logistic regression analyses were performed with mental health status as a dependent variable and other studied parameters as independent variables. RESULTS: A total of 21.0% of study participants (11.9% of men and 45.5% of women) showed bad mental health condition. Results of multivariate logistic regression analysis showed that "female" (odds ratio (OR) 11.94, 95% confidence interval (CI) 2.60 - 54.76, P = 0.001), "higher evaluation from one's surroundings for competition stressors" (OR 5.74, 95% CI 1.34 - 24.60, P = 0.019), and "lower social support from family members" (OR 3.97, 95% CI 1.03 - 15.25, P = 0.045) were the risk factors of bad mental health. CONCLUSIONS: The mental health status among visually impaired athletes might be almost the same level as non-visually impaired athletes and general population, and have relation to gender, stress of evaluation from surroundings during competition, and social support from family members. It may be necessary to pay attention especially to women, and improve one's surroundings of competition stressors and family social support to maintaining the mental health of visually impaired athletes.

Exercise or sports in midlife and healthy life expectancy: an ecological study in all prefectures in Japan.

BACKGROUND: With the increase of overall life expectancy in Japan, effective and beneficial lifestyle approaches and practices are crucial for individuals to have a long, productive and healthy life. Although previous studies suggest that exercise or sports, especially when performed with others, from midlife level have a positive impact on enhancing healthy life expectancy, there is paucity of information regarding these contexts and possible associations. The present study intends to clarify the relationship between engagement in exercise or sports among middle-aged persons and healthy life expectancy through an ecological study in all prefectures in Japan. METHODS: We tabulated (1) the ratios of middle-aged individuals engaged in exercise or sports and (2) the different methods by which they are engaged in exercise or sports for each prefecture by using data from the 2005-2010 Longitudinal Survey of Middle-aged and Elderly Persons by the Ministry of Health, Labour and Welfare of Japan. Weighted multiple linear regression analyses were performed by sex, using healthy life expectancy in 2010 of each prefecture calculated by Hashimoto (2013) as a criterion variable; indices of (1) and (2) of each year as explanatory variables; and age, living conditions, employment, and chronic diseases as adjusted variables. RESULTS: For middle-aged males, the ratio of those engaged in exercise or sports in each year from 2005 to 2010 was positively correlated with healthy life expectancy; this relationship was found in the ratio of middle-aged engaging in exercise or sports "with families or friends". For females, such a relationship could only be found in the ratio of middle-aged females engaged in exercise or sports in 2008 and 2010, and those engaging in exercise or sports "with families or friends" in 2008. CONCLUSION: Prefectures with a higher ratio of middle-aged individuals engaging in exercise or sports, especially when done with families or friends, have longer healthy life expectancies. This was particularly evident for males. Thus, exercise or sports with families or friends in midlife seems to be more effective in promoting healthy life expectancy for males than females in Japan.

Sleep disorder risk factors among student athletes.

OBJECTIVE: To clarify sleep disorder risk factors among student athletes, this study examined the relationship between lifestyle habits, competition activities, psychological distress, and sleep disorders. METHODS: Student athletes (N = 906; male: 70.1%; average age: 19.1 ± 0.8 years) in five university sports departments from four Japanese regions were targeted for analysis. Survey items were attributes (age, gender, and body mass index), sleep disorders (recorded through the Pittsburgh Sleep Quality Index), lifestyle habits (bedtime, wake-up time, smoking, drinking alcohol, meals, part-time jobs, and use of electronics after lights out), competition activities (activity contents and competition stressors), and psychological distress (recorded through the K6 scale). The relation between lifestyle habits, competition activities, psychological distress, and sleep disorders was explored using logistic regression analysis. RESULTS: Results of multivariate logistic regression analysis with attributes as adjustment variables showed that "bedtime," "wake-up time," "psychological distress," "part-time jobs," "smartphone/cellphone use after lights out," "morning practices," and "motivation loss stressors," were risk factors that were independently related to sleep disorders. CONCLUSIONS: Sleep disorders among student athletes are related to lifestyle habits such as late bedtime, early wake-up time, late night part-time jobs, and use of smartphones/cellphones after lights out; psychological distress; and competition activities such as morning practices and motivation loss stressors related to competition. Therefore, this study suggests the importance of improving these lifestyle habits, mental health, and competition activities.

The relationship between stressors and mental health among Japanese middle-aged women in urban areas.

In middle age, some people may become mentally or emotionally unstable. Additionally, in Japan, mood disorders, such as depressive symptoms, occur mostly among middle-aged women (i.e., aged 40-49 years). However, few studies have examined stressors related to mental health. In the present study, we developed a stressor scale for middle-aged women and examined stressors correlated with middle-aged women's mental health. In January 2015, an anonymous, self-administered survey was mailed to 1,000 randomly selected women aged 45 through 64 years living in Tokyo, Japan. Completed questionnaires were obtained from 329 women (32.9 percent). Factor analysis identified the following stressor categories: "relationship with my husband," "uneasiness about old age," "health concerns," "work-life balance," and "relationship with my friends." "Uneasiness about old age" and "health concerns" were correlated negatively with participants' mental health. Improving middle-aged women's health requires interventions that relieve stressors resulting from age-related problems and promote a positive image of old age.

Physical activities impact sense of coherence among community-dwelling older adults.

AIM: The objective of the present study was to investigate bidirectional longitudinal relationships between sense of coherence (SOC) and physical activities (PA) among community-dwelling older adults. METHODS: Self-administered questionnaires were sent to 508 community-dwelling adults aged 65-85 years who expressed their intention to participate in our surveys including cognitive function tests and physical performance tests. Of these, 427 people responded to the baseline survey, and 223 of them participated in the follow-up survey 1 year later. Finally, the number of eligible respondents who had no missing values in all data was 179 (valid response rate: 35.2%). We used the 13-item five-point version of the Sense of Coherence Scale to assess SOC variables, and the Physical Activity Scale for the Elderly to assess PA variables. A structural equation modeling method was used to analyze bidirectional longitudinal relationships between SOC and PA. Cross-lagged effects and synchronous effects models were applied to analyze these relationships. Demographic variables (age, sex, education, living arrangements, medical histories, employment status), cognitive function and physical performance were used as control variables. RESULTS: Leisure-time PA had a cross-lagged effect (ß = 0.117, P < 0.05) and a synchronous effect (ß = 0.217, P < 0.001) on SOC. In contrast, no significant effect of SOC on any type of PA was observed in either the cross-lagged effects model or the synchronous effects model. CONCLUSIONS: Leisure-time PA might contribute to enhancing SOC in community-dwelling older adults. Geriatr Gerontol Int 2017; 17: 2208-2215.

The Impact of Leisure and Social Activities on Activities of Daily Living of Middle-Aged Adults: Evidence from a National Longitudinal Survey in Japan.

This study investigated the effects of leisure and social activities on the ability of middle-aged adults to maintain activities of daily living (ADL), and whether performing these activities alone or with others contributed to the ability to perform ADL. The study used nationally representative longitudinal data of 22,770 adults in Japan, aged 50-59 years, who did not have limitations in performing ADL at the beginning of the 5-year survey period. The study considered six activity categories: two leisure activities ("hobbies or cultural activities" and "exercise or sports") and four social activities ("community events," "support for children," "support for elderly individuals," and "other social activities"). Multiple logistic regression analysis was used to examine the relation between participation in these categories at baseline and difficulties in ADL at the 5-year follow-up. The association between the extent of social interaction during these activities ("by oneself," "with others," or "both") and difficulties in ADL was also investigated. The analysis yielded significant negative correlations between "exercise or sports" and difficulties in ADL for both men and women, and between "hobbies or cultural activities" and difficulties in ADL for women. However, these significant relationships occurred only when activities were conducted "with others." The present findings might help prevent deterioration in middle-aged adults' performance of ADL in Japan.

Age and sex differences of risk factors of activity limitations in Japanese older adults.

AIM: The objective of the present study was to verify how socioeconomic and physical/mental health status would be associated with activity limitations by age and sex among older adults, using nationally representative cross-sectional data in Japan. METHODS: The present study focused on 8373 older adults aged 65 years or older extracted from the Comprehensive Survey of Living Conditions conducted in 2007 by the Japanese Ministry of Health, Labor and Welfare. Univariate and multiple logistic regression analyses and population-attributable risk were applied to validate the relationships of socioeconomic and physical/mental health status with activity limitations among the total population, and by age groups (young-old or old-old) and sex. RESULTS: Mental health showed the highest odds ratio and population-attributable risk in the total population. In addition, low back pain was associated with activity limitations regardless of age and sex. Other musculoskeletal diseases, such as arthropathy and osteoporosis, were related to activity limitations for women, regardless of age, whereas cardiovascular diseases, including angina pectoris/myocardial infarction and cerebral stroke, were associated with activity limitations for men in any age group. There were no statistically significant correlations between socioeconomic status and activity limitations in any groups. CONCLUSION: Mental health was the most important factor of activity limitations in Japanese older adults. Furthermore, low back pain regardless of age and sex, other musculoskeletal diseases only for women and cardiovascular diseases mainly for men could also be significant risk factors to activity limitations. Therefore, preventive approaches of activity limitations considering sex differences are important for older adults in Japan. Geriatr Gerontol Int 2015; ●●: ●●-●●.

How Possibly Do Leisure and Social Activities Impact Mental Health of Middle-Aged Adults in Japan?: An Evidence from a National Longitudinal Survey.

OBJECTIVES: This study aimed to investigate longitudinal relations between leisure and social activities and mental health status, considering the presence or absence of other persons in the activity as an additional variable, among middle-aged adults in Japan. This study used nationally representative data in Japan with a five-year follow-up period. METHODS: This study focused on 16,642 middle-aged adults, age 50-59 at baseline, from a population-based, six-year panel survey conducted by the Japanese Ministry of Health, Labour and Welfare. To investigate the relations between two leisure activities ('hobbies or cultural activities' and 'exercise or sports') and four social activities ('community events', 'support for children', 'support for elderly individuals' and 'other social activities') at baseline and mental health status at follow-up, multiple logistic regression analysis was used. We also used multiple logistic regression analysis to investigate the association between ways of participating in these activities ('by oneself', 'with others', or 'both' (both 'by oneself' and 'with others')) at baseline and mental health status at follow-up. RESULTS: Involvement in both leisure activity categories, but not in social activities, was significantly and positively related to mental health status in both men and women. Furthermore, in men, both 'hobbies or cultural activities' and 'exercise or sports' were significantly related to mental health status only when conducted 'with others'. In women, the effects of 'hobbies or cultural activities' on mental health status were no differences regardless of the ways of participating, while the result of 'exercise or sports' was same as that in men. CONCLUSIONS: Leisure activities appear to benefit mental health status among this age group, whereas specific social activities do not. Moreover, participation in leisure activities would be effective especially if others are present. These findings should be useful for preventing the deterioration of mental health status in middle-aged adults in Japan.